Zhen Lin

Integrated single-cell and bulk tissue analyses reveal distinct macrophage subtypes and a candidate prognostic signature in colorectal cancer: implications for tumor immune characterization

Introduction Colorectal cancer (CRC) represents a major global health burden, marked by high morbidity and mortality rates that place a considerable strain on healthcare systems. Methods This study leveraged integrated bioinformatic analyses, single-cell RNA sequencing, and clinical sample validation to investigate the...