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Open access Sep 2026

Genetic vulnerability and dynamic mechanical stress synergistically drive sarcomere failure in human iPSC-derived cardiomyocytes

Mechanical stress plays a critical role in regulating cardiomyocyte structure and physiology. However, mechanobiology studies still rely on static systems that failed to capture the progressive nature of native cardiac remodeling. Building on our prior shape memory polymer (SMP)-based platform, the present study integr...

Chen-Yan Wang, Nhu Y. Mai, Fred J. Donelson et al. · 0 citations
Open access Sep 2026

TH1834-Mediated TIP60 Inhibition Protects Against Ischemia/Reperfusion Damage in Human iPSC-Derived Cardiomyocytes and Cardioids

Ischemia/reperfusion injury limits functional recovery after myocardial infarction through mitochondrial dysfunction, oxidative stress, energetic failure, impaired calcium handling, and contractile dysfunction. We previously identified the acetyltransferase TIP60/KAT5 as a maladaptive regulator of post-ischemic cardiac...

Zhuo-Cheng Qu, Sakthika Murugesan, Julia Ma et al. · 0 citations
Open access Aug 2026

A Deep-Learning-Based Scoring Framework for Large-Scale Multi-donor Cardiotoxicity Screening

This framework establishes a scalable, human-relevant, and genetically diverse platform for cardiotoxicity surveillance across both pharmacological and environmental chemical spaces and identified microbiocides, dyes, and pesticides as chemical classes of potential concern.

Danny Vu, Andrew Kowalczewski, Sarah D. Burnett et al. · 0 citations

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