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Zhen-Qiu Liu

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Open access Sep 2026

Large-Scale Plasma Proteomics Reveals Preclinical Biomarkers of Incident Severe Liver Disease.

The absence of robust biomarkers for early detection of severe liver disease (SLD) highlights the critical need for high-throughput proteomics-driven discovery. In this prospective cohort study, we aimed to identify plasma protein signatures associated with incident SLD and assess their clinical utility. Using the larg...

Shu-Zhen Zhao, Cheng-Nan Guo, Xin Zhang et al. · 0 citations
Aug 2026

Multi-omics dissection of MASLD reveals divergent pathways to systemic diseases and targets for prevention.

BACKGROUND Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent but heterogeneous condition. How its genetic diversity shapes systemic disease risk remains unclear. We aimed to identify genetically defined MASLD subtypes, assess their effects on extrahepatic diseases, and uncover potential pr...

Yuxuan Weng, Mingyi Du, Tianhao Wu et al. · 0 citations

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