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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Zhen-Wei Zhang

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Sep 2026

Discovery of Dual PARP/GPX4 Inhibitors for the Treatment of Triple-Negative Breast Cancer

This work identified dual PARP/GPX4 inhibitors via a structure-based hybridization strategy and explored the dual-target antitumor effect in blocking the progression of TNBC, finding that compound 12 exhibited potent biochemical inhibitory activities against both PARP and GPX4.

Zi-An Wang, Rong-Ke Li, Jia-Dai Liu et al. · 0 citations
Jul 2026

Structure-Based Drug Design of Novel Indazole/Indolinone-Based Biaryl Derivatives as Oral IRAK4 Inhibitors for the Treatment of Inflammatory Diseases.

Compound 43 exhibited potent molecular and cellular IRAK4 inhibitory activities as well as in vivo anti-inflammatory activities in both LPS-induced acute inflammation and collagen-induced arthritis models alongside favorable pharmacokinetic properties, indicating that compound 43 is a valuable lead compound for further...

Zhen-Wei Zhang, Xue Wang, Xuan Luo et al. · 0 citations
Jul 2026

Discovery of Novel Anethole Trithione Derivatives Targeting SQR Pathway to Induce Mitochondrial Uncoupling for Stroke Treatment.

Hydrogen sulfide (H2S) is an endogenous gasotransmitter with therapeutic potential for stroke. Our previous work identified that ADT-OH, an H2S donor with mitochondrial uncoupling activity, protects against stroke by activating the SQR-UCP2-AMPK pathway. Here, we launched a medicinal chemistry campaign based on hit com...

Peng Song, Yuan Li, Xiaohan Song et al. · 0 citations

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