Author

Zhen Wu

2 papers indexed here

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Sep 2026

H3K27M drives OPC stemness and intrathecal therapeutic vulnerability in brainstem glioma organoids.

Brainstem gliomas, particularly H3K27M-mutant diffuse midline gliomas (DMGs), lack effective therapies owing to anatomic inaccessibility, intact blood-brain barrier, and treatment resistance. Conventional models have low establishment rates and fail to preserve the native tumor microenvironment, limiting translational...

Lu-Yang Xie, Zhuan-Xin Jiang, Hang Zhou et al. · Cell Stem Cell · 1 citation

Open access Aug 2026

Radiomics-guided multimodal MRI fusion framework for non-enhanced glioblastoma noninvasive identification

This study aimed to develop and externally validate a radiomics-based machine learning framework for the noninvasive differentiation of non-enhanced glioblastoma (NE-GBM) from astrocytoma, IDH-mutant, grade 2 (IDHm-A2), thereby addressing the diagnostic limitations of qualitative MRI and the challenge of data scarcity....

Shuai Liu, Xue-Xia Mao, Xing Liu et al. · PLOS Digital Health · 0 citations