Zhen-Yi Liu

An integrated network toxicology and multi-omics framework prioritizes BRCA1 as a testable candidate in benzo[a]pyrene-associated oral cancer

The current findings do not establish direct BaP–BRCA1 binding, direct regulation of BRCA1 by BaP, a definitive in vivo mechanism, or clinical causality, and require further validation through direct biochemical assays, additional experimental models, and exposure-annotated human cohorts.