Author

Zhenyu Han

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Sep 2026

Nanoconjugate Strategy Integrating Immunogenic Cell Death Induction and Innate Immune Activation for Potent Anti-Cancer Immunity.

In vivo immune modulation can potentially benefit broader cancer patients. Efficient cross-priming of anti-tumor T cells requires "three-signal" dendritic cells (DCs) that simultaneously integrate antigenic, co-stimulatory, and migratory programs, which remains a major challenge. Here, we developed a carrier-free pepti...

Teng-Yu He, Alexander M. Cryer, Daniela Simental Lopez et al. · Advances in Materials · 0 citations

Open access Aug 2026

Mechanical Caging of Nucleic Acids Enabled by Light-Activated Synthetic Molecular Motors.

Control over nucleic acid activity is central to biotechnology and therapeutic development. Most existing strategies rely on installing protecting groups that mask nucleobases or backbone functionalities (i.e., chemical caging), where modulation of activity arises from alteration of the biomolecule's chemical identity....

Yuchen Ma, Erika McCarthy, N. Murthy et al. · Angewandte Chemie · 0 citations

Open access Jul 2026

Diffraction-quality, ultraflexible protein single crystals engineered with DNA

This work reports a valence-centric strategy that enables DNA-bonded, protein single crystals with unconventional mechanical properties and establishes a programmable framework for biomolecular crystallization and nanomaterials engineering with atomic precision.

Zhenyu Han, C. Mirkin · Science Advances · 0 citations