Macrophage-Derived, Rather Than Microglial, Cathepsin B Exacerbates Brain Injury After Ischemic Stroke.
Neuroimmune responses critically shape the progression and outcome of ischemic stroke, yet the cell type-specific roles of myeloid populations remain incompletely defined. Cathepsin B (CatB), a lysosomal cysteine protease, has been implicated in neuroinflammation, but its contribution from distinct myeloid subsets is u...