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Author

Zhenbo Yuan

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Review Aug 2026

Construction of cell factories, and multi-enzymatic and chemoenzymatic cascades to enable the efficient production of alkaloids.

Covering: up to 2025Alkaloids constitute an invaluable reservoir for pharmaceutical discovery. However, their therapeutic development has long been constrained by the inefficiencies of plant extraction, as well as the economic impracticality of total chemical synthesis. In recent years, biomanufacturing has emerged as...

Zhenbo Yuan, Huiling Liu, Fei Li et al. · 1 citation
Aug 2026

Structure-Guided Engineering of Glycosyltransferase UGT73-327-2 Coupled with UDP-Glucose Regeneration Enables Highly Efficient Biosynthesis of Mogroside VI.

Mogroside VI (Mog VI) is a rare triterpene glycoside from Siraitia grosvenorii with promising bioactivities. However, its biosynthesis is limited by a single rate-limiting glycosylation step converting mogroside V, catalyzed by the inherently low-activity plant glycosyltransferase UGT73-327-2. In this study, we applied...

Dong Guo, Yan Zhang, Xupeng Guo et al. · 0 citations

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