Review
Open access
Sep 2026
Targeted protein degradation dismantles undruggable targets to reverse immune evasion and therapy resistance in cancer
This Review examines the molecular engineering principles of bifunctional degraders and summarizes clinical progress demonstrating synergy with immune checkpoint blockade and adoptive cell therapy, and discusses how catalytic protein elimination overcomes primary immune evasion and adaptive resistance driven by compens...
Fu-Rong Zhang, Qian-Heng Wang, Ming-Xuan Li et al.
· Frontiers in Immunology · 0 citations