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Zheng-Hong Yu

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Open access Aug 2026

TRIM25 facilitates mitochondrial dysfunction and extracellular matrix degradation by enhancing USP7‐driven ENO1 deubiquitination during intervertebral disc degeneration

Abstract Background The pathology of intervertebral disc degeneration (IDD) is characterized by metabolic dysregulation within nucleus pulposus (NP) cells. TRIM25 has been implicated in diverse tumors and pathological processes, yet its precise role in mediating mitochondrial function and metabolic alterations during I...

Xiao-Ming Liu, Wen-Yu Zhang, Hang Feng et al. · 0 citations

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