Aug 2026
Discovery of Cbl-b Targeting Cyclic Peptide Ligands by Phage Display.
Cbl-b is a RING-type E3 ubiquitin ligase and intracellular immune checkpoint that negatively regulates immune-cell activation. However, ligand discovery for Cbl-b remains limited, largely because the RING-type E3 ubiquitin ligase is regulated by shallow and extended protein-protein interaction interfaces that are diffi...
Xiao-Qin Yang, Ming Wei, Wei-Kang Zhai et al.
· Organic Letters · 0 citations