AI Networking Cookbook: Practical recipes for AI-assisted network automation and development
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DYNAMIC CONFORMATIONS IN THE ACTIVATION OF PINK1 KINASE
It is reported that Tribolium castaneum PINK1 (TcPINK1) forms specific symmetric dimers via interactions between the kinase N-lobe and the regulatory C-terminal domain, which provide a framework for understanding the conformational plasticity and allosteric regulation of PINK1 in mitophagy.
MOLECULAR BASIS FOR PINK1 MATURATION
A general mechanism for PINK1 recognition by the HSP90α/CDC37/FKBP51 chaperone complex is revealed and a potential approach for upregulating PINK1 activity, which is impaired in PD is suggested.