Bu Shen Huo Xue Formula ameliorates chronic kidney disease and suppresses NLRP3 inflammasome-mediated pyroptosis and renal fibrosis.
BACKGROUND Bu Shen Huo Xue Formula (BSHX) is used in traditional Chinese medicine for chronic kidney disease (CKD), but its pharmacological mechanisms remain unclear. This study investigated whether effects of BSHX against CKD are associated with modulation of NLRP3 inflammasome-mediated pyroptosis and the inflammation...