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Sep 2026

Bu Shen Huo Xue Formula ameliorates chronic kidney disease and suppresses NLRP3 inflammasome-mediated pyroptosis and renal fibrosis.

BACKGROUND Bu Shen Huo Xue Formula (BSHX) is used in traditional Chinese medicine for chronic kidney disease (CKD), but its pharmacological mechanisms remain unclear. This study investigated whether effects of BSHX against CKD are associated with modulation of NLRP3 inflammasome-mediated pyroptosis and the inflammation...

Xin-Yu Ma, Yuan-Yuan Deng, Jiang-Yuan Jin et al. · 0 citations
Jul 2026

Integrated network analysis, proteomics, and experimental validation reveal the mechanisms underlying the renoprotective effects of salvianolic acid A against diabetic nephropathy.

SAA exerts renoprotective effects against DN through modulation of PI3K/Akt/mTOR-mediated autophagy and macrophage polarization, leading to attenuation of oxidative stress, inflammatory responses, mitochondrial dysfunction, and macrophage polarization.

Zheng Luo, Yu Ma · 0 citations

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