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Author

Zheng-Wei Liu

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Aug 2026

Nitric oxide-assisted lipid nanoparticles amplify mRNA vaccine responses.

NO-assisted LNPs are established as a unique platform for potent mRNA delivery, which provides a new paradigm for overcoming endosomal barriers and improving the efficacy of mRNA vaccines.

Zheng-Wei Liu, Dinglingge Cao, Xu-Cheng Hou et al. · 0 citations
Open access Aug 2026

Overcoming the blood-brain barrier using central nervous system-accessing lipid nanoparticles for enhanced mRNA therapeutics.

This work designed, synthesized, and tested a series of ionizable lipids and formulated them into CNS-accessing lipid nanoparticles (CA LNPs) to deliver mRNA, and the lead candidate, CA2d LNP, demonstrated efficient mRNA delivery across the blood-brain barrier following intravenous injection.

Si-Yu Wang, Yi-Chen Zhong, Chang Wang et al. · 0 citations

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