Non-Canonical Function of ORC1: Regulating Notch-VEGFR2-Mediated Angiogenesis in Melanoma Progression.
Melanoma is an aggressive skin cancer characterized by high metastatic potential and substantial genetic heterogeneity. Although genome-wide association studies (GWAS) have identified numerous susceptibility loci, the functional roles of risk variants, most of which reside in non-coding regions, remain poorly understoo...