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Zheng-Yang Chen

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Open access Sep 2026

Integrated stress response inhibition decouples cardiotoxicity from anthracycline chemotherapy while enhancing antitumor efficacy.

The clinical efficacy of anthracycline chemotherapeutics is severely limited by their dose-dependent cardiotoxicity, a condition lacking effective preventive strategies. We identify the maladaptive ATF4-dependent integrated stress response (ISR) program as a central driver of this pathology. In murine models, ISR inhib...

Si-Min Yang, Zheng-Yang Chen, Hong-Li Zhang et al. · 0 citations

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