Zheng Zhang

Cytochrome P450 enzymes in the biosynthesis of bioactive diterpenoids from traditional chinese medicinal plants.

Cytochrome P450 enzymes play key catalytic roles in the biosynthesis of diterpenoid natural products from traditional Chinese medicinal plants. Operating through a conserved heme-thiolate catalytic cycle and Compound I-driven oxidation, these enzymes mediate most post-cyclization oxidative tailoring of diterpene scaffo...