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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Zheng-Zhong Xu

h-index 13 View on Semantic Scholar

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Open access Sep 2026

Mycobacterium tuberculosis Rv0158 negatively regulates the cGAS-STING pathway mediated type I IFN production and enhances intracellular survival.

Overall, the finding identified a new bacterial factor Rv0158, which improves the understanding of the immune evasion mechanisms of M. tb, and suggests that Rv0158 may indirectly facilitate STING degradation or modulate its stability through host-interacting partners.

Zheng-Zhong Xu, Min-Li Geng, Zhi-Hong Yao et al. · 0 citations
Sep 2026

Mycobacterium tuberculosis Rv3248c Inhibits Type I Interferon Response and Promotes Intracellular Survival by Mediating Ubiquitin-Proteasome-Dependent Degradation of TBK1

Findings identify a previously uncharacterized mechanism by which M. tb dampens the IFN-I response by targeting TBK1, highlighting Rv3248c as a contributor to pathogenesis and a potential therapeutic target.

Zheng-Zhong Xu, Min-Li Geng, Zhi-Fang Zhang et al. · 0 citations
Open access Jul 2026

SH3PXD2B is the critical host factor promoting the entry of mycobacteria

A genome-wide CRISPR-KO library is constructed and results indicate that SH3PXD2B is a critical host factor manipulated by M. bovis to promote macrophage phagocytosis and inhibit migration, thereby facilitating bacterial invasion and reveal a new pathogenic strategy.

Donghui Liu, Ting Zhang, Yu-jie Sheng et al. · 0 citations

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