Author

Zhenghao Cai

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Clinical trial Open access Aug 2026

A multicohort, biomarker-driven phase 2 trial of personalized total neoadjuvant therapy with targeted agents for high-risk rectal cancer (The TRAINER study)

This multicohort, single-center, phase II trial explored the efficacy and safety of a biomarker-driven total neoadjuvant therapy (TNT) regimen in high-risk locally advanced rectal cancer (LARC) patients. The regimen included induction chemotherapy (4 cycles of mFOLFOX6) with targeted agents (bevacizumab for cohort B an...

T. Ma, Jingyi Liu, Sen Zhang et al. · Signal Transduction and Targ... · 0 citations

Open access Jul 2026

An epithelial-mesenchymal transition-related gene signature predicts prognosis, immune infiltration, and drug sensitivity in colorectal cancer

A gene signature associated with epithelial-mesenchymal transition that integrates TME dynamics, prognosis prediction, and drug resistance assessment in CRC holds significant value for predicting clinical prognosis, immunotherapy responsiveness, and chemotherapy sensitivity in CRC.

Xiaonan Shen, Hao Zhong, Wenqing Jia et al. · Cancer Drug Resistance · 0 citations