Summary 5-Fluorouracil (5-FU)-based regimens are a cornerstone of colorectal cancer (CRC) chemotherapy. Levofloxacin (LVF), a widely used fluoroquinolone antibiotic, has been reported to exhibit anticancer properties. We investigated LVF’s ability to enhance CRC chemosensitivity to 5-FU in cell lines, subcutaneous xeno...
Chen-Meng Huang, Chen-Chen Sun, Han Wang et al.· iScience· 0 citations
Trichoxanes A (1) and B (2), two novel sorbicillinoids featuring a unique cage-like 2,7-dioxa-pentacyclo[7.4.0.03,8.05,13.06,10]tridecane scaffold, were isolated from Trichoderma reesei via a molecular networking strategy. Their structures were elucidated by spectroscopic analyses, CASE, DP4+ NMR calculations, and EC...
Rui Jiang, Xin-Yu Zheng, Xing-Piao Jin et al.· Organic Letters· 0 citations
Guided by molecular networking, HSQC-based DeepSAT, and SMART analyses, a chemical investigation of the coral-derived fungus Talaromyces sp. TJ403-AL05 led to the isolation and identification of taladipyrones A-I (1-9), a series of new α-pyrone dimers with four distinct skeletons. Among these, compounds 1 and 9 represe...
Han-Xiao Zeng, Yaxing Wang, Chen-Meng Huang et al.· Chinese Journal of Natural M...· 0 citations
The GNPS (Global Natural Products Social Molecular Networking) strategy enable the targeted isolation of eremophilane sesquiterpenoids from Penicillium roqueforti, a fungus isolated from the rhizosphere soil of Hypericum beanii N. Robson collected in the Shennongjia Forestry District, Hubei Province, China. The isolate...
Shu-Yuan Mo, Xiang-Man Shu, Jie Zhao et al.· Phytochemistry· 0 citations
Mechanistic investigations revealed that AKF treatment reduced EGFR expression and attenuated the phosphorylation of key components of the EGFR/PI3K/AKT signaling pathway, identifying AKF as a promising bioactive lead for further target validation and in vivo evaluation.
Jun Yao, Xing-Piao Jin, Wei-Wei Wang et al.· Bioorganic chemistry (Print)· 0 citations
(±)-Hypericandrone A and (+)-1 displayed potent antitubercular activity by selectively inhibiting the acetyltransferase domain of Mycobacterium tuberculosis GlmU through a dual mechanism, acting competitively against acetyl-CoA and noncompetitively against glucosamine-1-phosphate.
Non-small cell lung cancer (NSCLC) remains one of the leading causes of cancer-related mortality worldwide, highlighting the urgent need for effective therapeutic agents. Natural products represent an important source of novel anticancer compounds. In this study, we investigated the anti-NSCLC activity of 10,11-dehydro...
