Cluster of Differentiation 36-Engineered Photosynthetic Cyanobacteria Enable Immunometabolic Reprogramming in Triple-Negative Breast Cancer.
Triple-negative breast cancer (TNBC) exhibits profound resistance to immunotherapy, largely due to a tumor microenvironment constrained by dysregulated lipid metabolism and persistent hypoxia. Excessive fatty acid uptake mediated by the scavenger receptor CD36 (Cluster of differentiation 36) imposes metabolic stress on...