Aug 2026
Design, synthesis, biological activity and computational simulation evaluation of pyrimidine-2-aminoacetamide derivatives as cholinesterase inhibitors
Compound 17v represents a promising lead compound for anti-Alzheimer's therapy and may possess multi-target neuroprotective potential and a favorable preliminary safety profile, supporting its further investigation as a potential therapeutic candidate for Alzheimer’s disease.
Yi-Xuan Wang, Shi-Hao Qin, Qiang Liu et al.
· Medicinal Chemistry Research · 0 citations