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Zhenzhen Fan

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Review Open access Jul 2026

Research progress on the α-synuclein-lysosome axis in Parkinson’s disease: molecular mechanisms of protein aggregation, autophagy dysfunction, and therapeutic targeting

Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder worldwide, characterized pathologically by the loss of dopaminergic neurons in the substantia nigra and the formation of Lewy bodies, which predominantly consist of misfolded α-synuclein (α-Syn) aggregates. Recent advances have highlighted...

Jiao-Jiao Fu, Chuanxi Zhu, Zhenzhen Fan · 0 citations

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