Zhi-Bin Hu

Postnatal Ketone Deficiency Impairs Adult Oocyte Quality via Enhancing Histone Acetylation in Malnourished Mice.

Early postnatal life is important for reproductive development, but the effects of early-life nutrition on female reproductive capacity remain largely unknown. Here, we investigated whether neonatal ketone body deficiency affects adult oocyte quality using a lactational malnutrition model and Hmgcs2-deficient mice. We...

Genome-wide association analyses of gestational phenotypes identify context-specific genetic effects

Actionable genotypes beyond the coding sequence and their association with lifespan in the UK Biobank.

The findings demonstrate that functionally verified promoter variants represent a previously unrecognised determinant of mortality risk, highlighting the potential value of looking beyond coding sequences in future studies and provide clues that functional promoter variants may merit consideration when expanding action...

Functional noncoding variants within the TBX1 enhancer contribute to tetralogy of Fallot.

This study demonstrates the involvement of noncoding variants in the TBX1 enhancer in TOF pathogenesis, highlighting the feasibility of using organoids to decipher the underlying mechanisms of unconserved noncoding regions in developmental malformations.