Open access
Aug 2026
Celastrol ameliorates ulcerative colitis by inhibiting HSP90-mediated necroptosis of intestinal epithelial cells
Introduction Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by intestinal barrier dysfunction and epithelial cell death. Necroptosis of intestinal epithelial cells (IECs) mediated by the RIPK1/RIPK3/MLKL pathway has emerged as a key driver of UC progression. Celastrol, a bioactive compoun...
Ke-Yi Lu, Yuan-Yuan Wang, Yi-Fan Shi et al.
· Frontiers in Pharmacology · 0 citations