Zhi-Bo Liu

Tracing fucosylation and astrocyte-associated pathogenic pattern in major depressive disorder: evidence from machine learning-based multi-omics and clinical validation

Background Major depressive disorder (MDD) remains a debilitating psychiatric condition with substantial global prevalence. Emerging evidence highlights the role of aberrant fucosylation (FUS) and astrocyte dysfunction as key contributors to MDD pathogenesis; however, their reciprocal molecular interactions remain poor...