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Open access Sep 2026

Psychosocial status and long-term risk of depression in middle-aged adults: evidence from a prospective cohort study

Abstract Aims Psychosocial factors represent modifiable targets relevant to alleviate depression risk. While individual psychosocial risks are well-documented, their combined status across multiple life domains is underexplored. We aimed to construct a novel multidimensional composite score of psychosocial status and e...

Xun-Yin Zhang, Yan-Wei Sang, Meng-Zhuo Qiu et al. · 0 citations
Open access Jul 2026

The brain structure and immunometabolic mechanisms underlying the association between frailty and dementia

The positive association between frailty and dementia is mediated through multiple biological mechanisms pathways, including inflammation, metabolic dysregulation, and accelerated brain aging, underscore the importance of frailty-oriented preventive strategies against dementia.

Wen-Juan Chen, Jiahao Min, Peng Xu et al. · 0 citations

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