TGs have a favorable renal protective effect on DN animals, which can improve renal function, basic indicators, glucose and lipid metabolism, and renal tissue pathological changes, but the intervention time and dose should be strictly restricted to prevent potential hepatotoxicity and hematological toxicity.
Meng He, Wei-Yi Feng, Cheng-Cheng Xu et al.· Frontiers in Pharmacology· 0 citations
Background Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease in which genetic susceptibility interacts with epithelial, immune, and mesenchymal remodeling. Although the chromosome 11p15.5 locus contains established IPF susceptibility signals near MUC5B and TOLLIP, the broader regulatory arc...
Gang-Gang Li, Xiaochuan Pan, Yuanyuan Wang et al.· Frontiers in Immunology· 0 citations
A two-sample Mendelian randomization analysis indicated that genetic liability to AD is associated with a lower risk of developing IPF, and APOE functions as a vital metabolic barrier against pro-fibrotic macrophage polarization in the lung.
Bing Bai, Le Chang, Zhi Cheng et al.· Frontiers in Immunology· 0 citations
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