Sep 2026
Mycobacterium tuberculosis Rv3248c Inhibits Type I Interferon Response and Promotes Intracellular Survival by Mediating Ubiquitin-Proteasome-Dependent Degradation of TBK1
Findings identify a previously uncharacterized mechanism by which M. tb dampens the IFN-I response by targeting TBK1, highlighting Rv3248c as a contributor to pathogenesis and a potential therapeutic target.
Zheng-Zhong Xu, Min-Li Geng, Zhi-Fang Zhang et al.
· ACS Infectious Diseases · 0 citations