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Author

Zhi-Fang Zhang

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Sep 2026

Mycobacterium tuberculosis Rv3248c Inhibits Type I Interferon Response and Promotes Intracellular Survival by Mediating Ubiquitin-Proteasome-Dependent Degradation of TBK1

Findings identify a previously uncharacterized mechanism by which M. tb dampens the IFN-I response by targeting TBK1, highlighting Rv3248c as a contributor to pathogenesis and a potential therapeutic target.

Zheng-Zhong Xu, Min-Li Geng, Zhi-Fang Zhang et al. · 0 citations

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