Mechanobiology of Osteoarthritis: Interactions Between Mechanical Stress, Inflammation, and Joint Remodeling.
Osteoarthritis (OA) is a multifactorial whole joint disease characterized by cartilage degeneration, subchondral bone remodeling, synovial inflammation, and progressive functional impairment. Increasing evidence suggests that OA is not simply a wear and tear disorder, but a mechanobiological disease in which abnormal m...