Clonal hematopoiesis (CH) is an early indicator of hematologic malignancies, driven by mutations in hematopoietic stem cells (HSCs) such as TET2 or P53. Recently ZBTB33 mutations have been implicated in myelodysplastic syndromes (MDS) and suggested as a driver of CH. However, the role of ZBTB33 in hematopoiesis and its...
Introduction Dermatomyositis (DM), particularly the anti-TIF1γ‑positive subtype, is associated with a substantially elevated risk of malignancy. However, the peripheral immune landscape of this autoantibody-defined subset, especially in patients without concurrent cancer, remains incompletely understood. Methods We per...
Xiao-Guang Cui, Kai-Hong Ye, Hong Wang et al.· Frontiers in Immunology· 0 citations
Findings establish the CME/RAB31 pathway as an indispensable regulator of TAM polarization, underscoring the pivotal role of vesicular trafficking in the TME.
Jing-Jing Liu, Shan-Shan Wang, Deng-Yi Bao et al.· Journal for ImmunoTherapy of...· 0 citations
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