Dynamic Covalent Prodrug Nanocomplex for Ultrasound-Triggered Oxidative Stress Amplification and Synergistic Sonochemotherapy.
Essential micronutrient Vitamin B2 (VB2) is a bioactive compound with sonodynamic activity; however, it suffers from hydrophilic limitations. Herein, a dynamic prodrug nanocomplex (PTX-PBA/VB2) was constructed via phenylboronic acid-diol interaction between VB2 and phenylboronic acid-functionalized paclitaxel prodrug (...