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Author

Zhi-Hao Chen

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Open access Sep 2026

ISGylation promotes ALDOA stability and PKM2-dependent activation to fuel colorectal cancer metabolism

ISG15 overexpression in cancers has emerged as a diagnostic marker and therapeutic target. This study identifies ISGylation, a post-translational modification mediated by ISG15, as a critical driver of CRC progression through metabolic reprogramming and oncogenic signaling. Clinical and multi-omics analyses reveal el...

Ye Wang, Peng Yang, Chi Jin et al. · 0 citations
Open access Aug 2026

Transcription Factor HOXC11 Drives Colorectal Cancer Progression and Metastasis via CAMK2A‐Dependent CXCL5 Upregulation

ABSTRACT Colorectal cancer (CRC) remains a leading cause of cancer mortality, and the molecular drivers of progression and distant metastasis are incompletely understood. By integrating differential expression and survival analyses of TCGA CRC cohorts with HOX family genes, we identified HOXC11 as a key metastasis‐asso...

Qingyang Sun, Hengjie Xu, Sheng‐Li Yang et al. · 0 citations
Jul 2026

Proteomic profiling reveals novel insights into hypercortisolism adrenal adenomas.

Comprehensive proteomic profiling of adrenal cortisol-producing adenomas reveals a central role for cholesterol metabolic reprogramming in the pathogenesis of CPAs and downregulation of calcium binding protein 39 like (CAB39L) is uncovered as a key driver of pathological cortisol production.

Xuyang Shi, Yi Yang, Chunxue He et al. · 0 citations

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