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Zhi-Hao Zhang

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Open access Sep 2026

Artificial intelligence for white matter hyperintensity segmentation: performance, determinants, and clinical implications

AI demonstrates promising performance for automated WMH segmentation, with U-Net–based architectures showing superior accuracy, however, substantial heterogeneity highlights the need for standardized imaging protocols and robust external validation.

Jin-Hua Hu, Zhi-Hao Zhang, Peng Lei et al. · 0 citations
Open access Aug 2026

MTHFR C677T and A1298C polymorphisms in dementia susceptibility: evidence from a meta-analytic investigation with disease-specific and ethnicity-stratified analyses

Background Alzheimer’s disease (AD) and vascular dementia (VaD) have become significant global health challenges. Recent research evidence indicates a close comorbidity between AD and cerebral small vessel disease. The C677T (rs1801133, also known as c.665C > T) and A1298C (rs1801131) polymorphisms in the methylenetetr...

Yu-Yao He, Yan-Dan Shi, Jin-Hua Hu et al. · 0 citations
Open access Jul 2026

Integrated multi-omics analysis suggests a potential mechanism of DEHP-induced monocyte infiltration in MASH via the FOS-CCL3/4 axis.

A potential mechanism by which DEHP exposure may promote monocyte infiltration and exacerbate MASH pathogenesis is suggested, potentially by interacting with and inhibiting the core regulatory protein FOS, thereby relieving its suppressive effect on CCL3/CCL4.

Chaojie Wang, Zhi-Hao Zhang, Yuqing Huang et al. · 1 citation

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