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Author

Zhi-Heng Dong

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Aug 2026

Network pharmacology-based identification and validation of novel vaccine candidates against brucellosis.

The development of a multi-epitope messenger RNA (mRNA) vaccine candidate targeting Brucella melitensis, the most pathogenic species responsible for human brucellosis is reported, establishing a promising platform for Brucella vaccine development warranting further evaluation in large animal models and human clinical t...

Zhi-Heng Dong, Sha Li, Jiarong Guo et al. · 0 citations
Open access Aug 2026

Integrated multi-omics strategy for screening novel protective antigens against Brucella melitensis and analysis of their immunogenicity

Through multi-omics integration analysis, this study successfully identified a novel candidate antigen, BMEI1943, with strong Th1-type immunogenicity, providing an experimental basis for the development of safe and efficient subunit vaccines against brucellosis.

Zhi-Heng Dong, Sha Li, Jiarong Guo et al. · 0 citations

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