Zhi-Hong Wu

When metagenomic next-generation sequencing detects Nocardia: from clinical interpretation to immune-based clinical management

Background Metagenomic next-generation sequencing (mNGS) increasingly detects Nocardia, but interpreting positive results remains challenging. We aimed to identify host factors and read thresholds that distinguish nocardiosis (ND) from colonization/contamination, and to characterize clinical features linked to immune s...