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Author

Zhihong Zuo

2 papers indexed here

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Review Open access Sep 2026

Evolution of Macrophage Function in Sepsis-Induced Cardiomyopathy: Cellular Networks from Immune Imbalance to Myocardial Injury.

Sepsis-induced cardiomyopathy (SICM) is an acute, often reversible myocardial depression driven by the host response to infection. Cardiac macrophages are central signaling hubs that integrate systemic danger signals and orchestrate myocardial dysfunction. We introduce a "Macrophage Functional Continuum" model, concept...

Wen-Ye Xu, Xian-Wen Wang, Jin-Wei Dai et al. · 0 citations
Aug 2026

Haemophilus-Informed Genetic and Transcriptomic Analyses Identify IL-7 and Vegfa as Drivers of Immunosuppressive Sepsis Endotypes.

BACKGROUND Sepsis exhibits marked biological heterogeneity, yet the causal pathways linking host immune mediators to clinically relevant endotypes remain poorly defined, particularly in pathogen-specific contexts. METHODS We applied Mendelian randomization (MR) to investigate the causal effects of circulating immune...

Jin-Wei Dai, Nianzhe Sun, Li-Na Zhang et al. · 0 citations

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