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Author

Zhi-Kai Zheng

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Open access Sep 2026

A microbial chromatin remodeler drives gastric cancer progression and immune evasion by reprogramming the host epigenome.

First-line treatment for gastric cancer (GC) includes PD-1 blockade with chemotherapy, but resistance challenges treatment success. We identify Streptococcus anginosus (SA) as a tumor-resident oncobacterium driving GC progression and immune evasion. SA is enriched in GC patient tumors and drives tumor growth in mice. S...

Xiao-Shan Xie, Yue Wei, Jia-Ying Zheng et al. · 0 citations

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