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Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

Author

Zhi-Min Gu

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Sep 2026

Inducing oxidative stress by targeting the cholesterol biosynthesis pathway augments the efficacy of bortezomib in multiple myeloma.

Proteasome inhibitors, particularly bortezomib (BTZ) which induces oxidative stress, remain the cornerstone of multiple myeloma (MM) therapy. However, resistance driven by metabolic reprogramming and redox adaptation limits their long-term efficacy. Here, we identify a cholesterol biosynthesis-dependent antioxidant mec...

Chun-Fan Li, Fu-Bo Wang, Hong-Wei Peng et al. · 0 citations
Open access Jul 2026

A functional genomics-pharmacotranscriptomics framework identifies host-directed anti-influenza agents

An integrative host-directed drug discovery framework combining functional genomics and pharmacotranscriptomics is developed, providing a systematic and scalable strategy for discovering antivirals that are less susceptible to resistance and potentially applicable to other rapidly evolving pathogens.

Jianfa Qiu, Xuecong Xing, Jing-Feng Wang et al. · 0 citations

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