Sep 2026
MMSDH facilitates ACSL4 propionylation to counteract ferroptosis upon hypoxia and impairs PDAC chemotherapy efficacy.
Pei-Xiang Zheng, Yan-Ni Lin, Mei-Yin Zhang et al.
· Nature Cancer · 0 citations
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Aug 2026
Reprogramming of lipid metabolism by PFKL promotes the adaptation of pancreatic ductal adenocarcinoma to glucose deprivation.
PFKL plays a key role in coordinating LD-mitochondria tethering under glucose deprivation in PDAC, and targeting the p38-PFKL-PLIN2-CPT1A axis may represent a promising therapeutic strategy.
Lu Chai, Zhaoyuan Meng, Zhi-Min Lu et al.
· Cellular Signalling · 0 citations