The nervous and immune systems interact to form a complex network that sustains homeostasis and finely tunes immune responses. These interactions significantly influence the pathogenesis and progression of various diseases, such as tumors, immune-related disorders, and infections. Consequently, these interactions have...
Qing-Yuan Zhuang, Si-Wei Zhang, Zhi-Ming Shao et al.· Signal Transduction and Targ...· 0 citations
It is discovered that NANS-mediated recruitment of USP7 stabilizes LATS2, driving tumor growth and resistance to endocrine therapy and CDK4/6 inhibitors in breast cancer.
Jia-Yang Cai, Minhua Huang, Shao-You Yang et al.· Nature Communications· 0 citations
This framework integrates evidence level, disease stage, biomarker reliability and patient tolerance into treatment selection for TNBC precision therapy and distinguish them from maturing or exploratory strategies such as pathway-directed therapy, epigenetic modulation, anti-vascular combinations, regulated cell-death...
Zi-Xun Wang, Xi-Yu Liu, Yu-Xiao Wu et al.· Journal of Hematology & Onco...· 0 citations
A role of ZNF689 is identified in regulation of homologous recombination repair via stabilization of the MRN complex, with ZNF689 deficiency conferring sensitivity to PARP inhibition, which upregulates PD-L1 expression and sensitizes tumors to combination therapy with anti-PD-L1 in TNBC.
