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Author

Zhi-Ming Wu

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Oct 2026

Icariin Protects Against Mitochondrial Damage and Ferroptosis-Related Injury in Synovial Fibroblast-Like Synoviocytes Through SUMO1-Dependent Regulation of SIRT1.

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation and progressive joint destruction, in which fibroblast-like synoviocytes (FLSs) play a central pathogenic role. Ferroptosis and oxidative stress-driven mitochondrial dysfunction have recently been implicated in s...

Zhi-Ming Wu, Ze-Qing Mao, Jian Guo et al. · 0 citations
Open access Oct 2026

UCHL5 stabilizes ALK5 to promote autophagy dependent ferroptosis in osteoarthritis

Ferroptosis is recognized as a key driver in the pathological progression of osteoarthritis (OA), but its regulatory mechanisms remain incompletely understood. To address this gap, we focused on the deubiquitinating enzyme UCHL5, which is implicated in OA progression, to elucidate its function in modulating ferropt...

Rilong Jin, Chen Li, Ming-Feng Xiong et al. · 0 citations

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