Open access
Sep 2026
Activation of TREM2 via single-domain antibodies improves synaptic and cognitive function in 5×FAD mice.
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder, and dysfunction of triggering receptor expressed on myeloid cells 2 (TREM2) in microglia increases AD risk. TREM2 activation promotes protective microglial functions and mitigates AD pathology. Although TREM2-activating antibodies show therapeut...
Xiao-Xiao Yu, Qiao-Yun Ren, Yan-Chun Gao et al.
· Cell Reports · 0 citations