Open access
Aug 2026
Compartmentalized B cell-microglia crosstalk drives ischemic white matter demyelination
Ischemic white matter injury and the consequent neuroimmune response can contribute to vascular cognitive impairment. The role of B cells in ischemic white matter injury is unclear. Here, we show that crosstalk between meningeal B cells and CNS-resident microglia exacerbates white matter injury and vascular cognitive i...
Lu-Lu Xu, Sheng Yang, Li-Fang Zhu et al.
· Nature Communications · 0 citations