Author

Zhi-Qiang Wang

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Open access Aug 2026

WaaL–WaaP receptor cross-talk drives phage-induced collateral sensitivity to colistin in Salmonella Pullorum

Phage therapy typically fails when bacteria rapidly evolve resistance, yet the inevitable fitness costs of escape mutants remain underexploited. In this study, an iterative and targeted phage-cocktail formulation strategy (ITPFS) was presented and developed. A potent lytic phage, PHZ055, was firstly isolated against a...

Mian-Zhi Wang, Yiwen Ren, Lei Jiang et al. · Veterinary Research · 0 citations

Open access Aug 2026

Dietary soy fiber limits Salmonella infection by disrupting the self-reinforcing loop between pathogen virulence and host inflammation.

The global threat of Salmonella Enteritidis (S. Enteritidis) is exacerbated by its ability to exploit host inflammation for colonization. Here, we find that dietary soy fiber (SF) confers colonization resistance by suppressing S. Enteritidis virulence and host inflammatory amplification. We identify harmaline (HAL), de...

Wei Liu, Jin-Ju Cai, Yan-Hu Huang et al. · Cell Reports · 0 citations