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Author

Zhi-Tong Zhou

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Open access Sep 2026

SGLT2 inhibitor ameliorates hypertension by regulating the CYP4A/20-HETE pathway in the kidney

Abstract Sodium–glucose transport protein 2 inhibitors (SGLT2i), initially developed as antidiabetic agents and now established as foundational therapies for heart failure, have also shown antihypertensive effects in clinical trials involving patients with diabetes and heart failure. However, the underlying mechanisms...

Zhi-Tong Zhou, Wei-Jian Hang, Rui Zhao et al. · 0 citations
Jul 2026

Comorbid Insomnia is Associated with Enhanced Blood Pressure Reduction with CPAP Therapy in Patients with Obstructive Sleep Apnea: A Prospective Cohort Study.

COMISA identifies a clinical phenotype with an enhanced SBP-lowering response to CPAP, particularly for achieving clinically meaningful 24-hour SBP reduction, suggesting that addressing both sleep disorders may optimize cardiovascular outcomes.

Shuang Li, Yuanni Jiao, Zhi-Tong Zhou et al. · 0 citations

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