Open access
Aug 2026
Covalent allosteric inhibition of AARS1 lactyltransferase
Alanyl-tRNA synthetase 1 (AARS1) was recently identified as a lactyltransferase responsible for protein lactylation, a modification associated with epigenetic regulation and metabolic adaptation. Here, we report compound XY353, which covalently binds C184 of AARS1, inducing steric clashes with F175 and triggering struc...
Yun-Yuan Huang, Si-Ying Liu, Lu-Yang Tian et al.
· Nature Communications · 0 citations