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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Zhiwei Chen

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2 papers indexed here

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Open access Sep 2026

TMEM59L promotes neuroendocrine differentiation and enzalutamide resistance in prostate cancer by regulating MUC1/β‐catenin/MYC axis

Abstract Background Enzalutamide resistance in advanced prostate cancer often leads to treatment‐induced neuroendocrine prostate cancer (t‐NEPC), characterized by aggressive lineage plasticity. The molecular regulators governing neuroendocrine differentiation and phenotypic transition are not well understood. Here, we...

Xiu-Chen Guo, Yi-Fan Liu, Jia-Cheng Huang et al. · 0 citations
Open access Jul 2026

MANF safeguards mitochondria-associated endoplasmic reticulum membrane integrity in nucleus pulposus-derived mesenchymal stem cells to maintain homeostasis of the intervertebral disc.

BACKGROUND Intervertebral disc (IVD) degeneration (IDD) is a leading cause of low back pain, with limited treatment options. The degenerative disc's harsh microenvironment promotes nucleus pulposus-derived mesenchymal stem cells (NP-MSCs) death and hinders self repair. Mesencephalic astrocyte-derived neurotrophic facto...

Chen-Hao Zhao, Liang Kang, Jiaqi Wang et al. · 0 citations

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