Zhiyuan Bai

Bisphenol A and prostate cancer: from population exposure to context-dependent mechanisms and translational implications

Bisphenol A (BPA) is a widespread endocrine-disrupting chemical with potential relevance to prostate cancer. This review provides a BPA-centered synthesis of evidence from human epidemiological studies, animal models, human prostate tissue and human-derived systems, and mechanistic investigations, while considering maj...

Lactate-associated H3K18la upregulates RNF166 to promote immune evasion in hepatocellular carcinoma by remodeling c-Jun ubiquitination

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality, and PD-L1-mediated immune evasion is a major mechanism of tumor immune suppression and an important target of immune checkpoint blockade. Here, we identified RNF166 as an E3 ubiquitin ligase that promotes immune evasion in HCC. RNF166 expres...

Burden of bladder cancer in China from 1990 to 2023: temporal trends, modifiable risk factors, and implications for prevention.